Even E-Cigarettes Can Cause Liver Diseases as Higher Nicotine Accumulates Fat in Liver

Even e-cigarettes can cause liver diseases, according to the new research conducted on mice suggesting that higher amount of nicotine contained in electronic cigarettes can be lead to building-up of more fat in the liver.

All the findings of the research were presented at the 100th annual meeting – ENDO 2018 by the Endocrine Society on Sunday, March 18 held in Chicago, Ill. to conduct the study which lasted for 12 weeks, the team of researchers separated the mice into two sets, from which one was set to be exposed to saline aerosol, while other group was exposed to the e-cigarette aerosol.


The team then observed 433 genes with some changes, which were related to the fatty liver progression and development in the group of mice exposed to the e-cigarettes. The teams also observed that the genes associated to the body clock – circadian rhythms were changed in the same group of mice. Circadian rhythm dysfunction is referred to speed up the progression of liver diseases that includes fatty liver diseases too.

Theodore C. Friedman, M.D., Ph.D., leading author of the study, Endowed Professor of Cardio-Metabolic Medicine and Chairman of the Department of Internal Medicine at the Charles R. Drew University of Medicine & Science in Los Angeles, California, said in a statement that, “The popularity of electronic cigarettes has been rapidly increasing in part because of advertisements that they are safer than conventional cigarettes.”

“But because extra fat in the liver is likely to be detrimental to health, we conclude that e-cigarettes are not as safe as they have been promoted to consumers. This has important public health and regulatory implications”, Friedman added.