Midlife shrinkage Is Associated with Dementia, study shows

Researchers unveiled that midlife inflammation can leads to brain shrinkage later in life that signals warning signs of Alzheimer’s disease or dementia. Now, scientists are pushing for more early findings, by suggesting early lifestyle changes which can avoid the disease’s destruction of the brain.

The latest findings published in the journal Neurology revealed an association between dementia and inflammation. The findings specified that inflammation promotes body’s immune cells in response to harms like smoking, stress, illness or poor diet.

The team of researchers observed 1,633 people with an average age of 53. They performed blood testing for levels of five markers of inflammation. They tested their blood throughout the body including the white blood cell count.

Around 24 years later, researchers carried a memory test and brain scans of the participants.

The result found that, participants who had higher levels of inflammation at midlife on three or more biomarkers had an average five percent lower brain volume and some areas associated with Alzheimer’s disease.

Some participants who had higher levels of inflammation also performed worse on a memory test.

But it’s not clear yet that whether inflammation could be causing brain shrinkage or if it is a reaction to other damaging processes.

Director of Research at Alzheimer’s Research UK, Carol Routledge, said, “The researchers measured levels of inflammation at a single point in time and we don’t know whether this gives a reliable indication of inflammation more generally.”

Researchers suggests that eating a healthy balanced diet, taking regular exercise and managing diabetes and high blood pressure can contribute major role in avoiding the symptoms of Alzheimer’s disease.